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KMID : 0380020050200010046
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Korean Journal of Biotechnology and Bioengineering
2005 Volume.20 No. 1 p.46 ~ p.49
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pH-Sensitive Release of Indomethacin from Curdlan Acetate Microspheres
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Lee Chang-Moon
Lee Young-Jin
Kim Hyung-Joo
Park Hee-Jung
Lee Ki-Young
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Abstract
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Curdlan, a natural has been studied as drug carrier due to its unique properties including its thermal gelling characters. In this study, curdlan was chemically acetylated for pH-sensitive drug delivery. Curdlan acetate microspheres(CAMs) were prepared by the solvent evaporation method. The size of the CAMs was below The drug loading efficiency of microspheres was approximately . In the swelling test, the CAMs showed pH-sensitive behavior. The swelling capacity of microspheres at pH 7.4 was much greater than at pH 1.4. Also, release rate of indomethacin(IND) at pH 7.4 from the CAMs was faster than that at pH 1.4. Therefore the CAMs have potential for the controlled release of IND over an extended period of time.
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KEYWORD
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Curdlan, indomethacin, pH-sensitive, microsphere
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